Evaluation of Some Renal Function Parameters in Rats Treated with Acrylamide

Acrylamide is a substance occured carbohydrate-rich foods during cooking high temperature and because of its small and hydrophilic structure, it can diffuses easily throughout the body. Due to this reason all tissues teorically become the target according to the acrylamide toxicity. In this study it was investigated whether acrylamide has any effect on the renal function of the male and female rats receiving long term acrylamide. In total, 25 male and 25 female Wistar rats were involved in this experiment. Animals in each sex were segregated into three groups. Two of them were treatment groups and one of them was control group. Each treatment group consisted of ten animals and each control group consisted of five animals. Acrylamide was administered to the treatment groups at 2 and 5 mg/kg/bw/day via drinking water for 90 days. At the end of the experiment, plasma samples were analyzed for sodium, potassium, chlor, calcium, phosphor, urea, uric acid and creatinine levels with the spectrophotometric method. At the end of the study it was observed that serum urea and creatinin levels statistically increased in the male and female rats just treated with 5 mg/kg/bw/day acrylamide (p<0.05) when compared to the rats treated with 2 mg/kg/bw/day acrylamide and control groups. Besides this there was no statistically difference serum sodium, potassium, chlor, calcium, phosphor and uric acid levels in rats treated with 2 and 5 mg/kg/bw/day acrylamide when compared to the control groups (p>0.05). According to the our findings it was possible to say that acrylamide treatment affects negativelly renal function in rats. In parallel with this the finding of acrylamide in most consumed foods such as potato chips may have negative effect on human health.